Interventional Stroke Therapies in the Elderly: Are We Helping?



Interventional Stroke Therapies in the Elderly: Are We Helping?

  1. N. Zeevi
  2. G.A. Kuchel
  3. N.S. Lee
  4. I. Staff and 
  5. L.D. McCullough
    Louise D. McCullough, MD, PhD, The Stroke Clinic at Hartford Hospital, 80 Seymour St, Suite JB603, Hartford, CT 06102; e-mail:lmccullough@uchc.edu

Abstract

BACKGROUND AND PURPOSE: It is unclear whether endovascular therapies for the treatment of AIS are being offered or are safe in older adults. The use and safety of endovascular interventions in patients older than 75 years of age were assessed.

 

MATERIALS AND METHODS: A retrospective review of patients with AIS 75 years or older (n = 37/1064) was compared with a younger cohort (n = 70/1190) by using an established data base. Admission and discharge NIHSS scores, rates of endovascular treatment, SICH, in-hospital mortality, and the mBI were assessed.

 

RESULTS: Rates of endovascular treatments were significantly lower in older patients (5.9% in the younger-than-75-year versus 3.5% in the older-than-75-year cohort, P = .007). Stroke severity as measured by the NIHSS score was equivalent in the 2 age groups. The mBI at 12 months was worse in the older patients (mild or no disability in 52% of the younger-than-75-year and 22% in the 75-year-or-older cohort, P = .006). Older patients had higher rates of SICH (9% in younger-than-75-year versus 24% in the 75-year-or-older group, P = .04) and in-hospital mortality (26% in younger-than-75-year versus 46% in the 75-year-or-older group, P = .05).

 

CONCLUSIONS: Patients older than 75 years of age were less likely to receive endovascular treatments. Older patients had higher rates of SICH, disability, and mortality. Prospective randomized trials are needed to determine the criteria for selecting patients most likely to benefit from acute endovascular therapies.

 

Abbreviations

AIS 
 
acute ischemic stroke 
 
HIAT 
 
Houston intra-arterial therapy 
 
IA
 
intra-arterial
 
ICH
intracranial hemorrhage
 
INR
 
international normalized ratio
 
IQR
 
interquartile range
 
LDL
low-density lipoprotein
 
mBI
 
modified Barthel Index
 
SICH
 
symptomatic intracranial hemorrhage
 
TIMI
 
thrombolysis in myocardial infarction




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