Higher Incidence of In-Hospital Complications in Patients With Clipped Versus Coiled Ruptured Intracranial Aneurysms




An excellent paper from Toronto. the authors have examined the  Registry of the Canadian Stroke Network to evaluate 931 patients and found significantly increased complication rates, mortality, increased hospital stay in patients undergoing clipping as opposed to coiling.

Link to the article in the journal website

Higher Incidence of In-Hospital Complications in Patients With Clipped Versus Coiled Ruptured Intracranial Aneurysms

  1. Mervyn D.I. Vergouwen, MD, PhD
  2. Jiming Fang, PhD;
  3. Leanne K. Casaubon, MD, MSc, FRCPC
  4. Melissa Stamplecoski;
  5. Annette Robertson, RN, RDCS
  6. Moira K. Kapral, MD, MSc, FRCPC;
  7. Frank L. Silver, MD, FRCPC on behalf of the Investigators of the Registry of the Canadian Stroke Network
From the Department of Medicine, Division of Neurology (M.D.I.V., L.K.C., F.L.S.) and Division of General Internal Medicine and Clinical Epidemiology and Women's Health Program (M.K.K.), University Health Network, University of Toronto, Toronto, Canada; Utrecht Stroke Center, Department of Neurology and Neurosurgery (M.D.I.V.), University Medical Center Utrecht, Utrecht, the Netherlands; the Department of Health Policy, Management and Evaluation (M.K.K.), University of Toronto, Toronto, Canada; the Institute for Clinical Evaluative Sciences (J.F., M.S., A.R., M.K.K., F.L.S.), Toronto, Canada; and the Canadian Stroke Network (M.K.K., F.L.S.).
  1. Correspondence to Mervyn D.I. Vergouwen, MD, PhD, Utrecht Stroke Center, Department of Neurology and Neurosurgery, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands. E-mailm.d.i.vergouwen@umcutrecht.nl

Abstract

Background and Purpose—After aneurysmal subarachnoid hemorrhage (SAH), patients with clipped aneurysms have a higher incidence of neurocognitive deficits and seizures compared with patients with coiled aneurysms. It remains unknown if patients with clipped aneurysms also have a higher incidence of other in-hospital complications.
Methods—We used data from the Registry of the Canadian Stroke Network on consecutive patients admitted to hospital with aneurysmal SAH. Patients who died within 2 days after admission were excluded. Baseline characteristics, incidence of various in-hospital complications within 30 days after admission, length of stay, poor functional outcome (modified Rankin Scale score at discharge of ≥3), and mortality were compared between patients with clipped versus coiled aneurysms.
Results—Of the 931 patients, 548 (59%) were clipped and 383 (41%) coiled. Baseline characteristics were similar. Compared with patients with coiled aneurysms, patients with clipped aneurysms had a higher incidence of in-hospital complications (37.2% versus 24.5% of patients; P<0.0001), poor functional outcome at discharge (69.4% versus 51.4%; P<0.0001), mortality (at discharge: 14.6% versus 9.1%; P=0.01), and a longer length of stay (17 [interquartile range, 11 to 29] versus 13 [interquartile range, 7 to 22] days; P<0.0001). Higher incidences were observed for urinary tract infection (P=0.02), pneumonia (P=0.01), cardiac/respiratory arrest (P=0.007), seizure (P=0.01), and decubitus ulcer (P=0.02). Urinary tract infection, pneumonia, cardiac/respiratory arrest, and seizure were independent predictors of poor functional outcome.
Conclusions—Patients with clipped aneurysms have a higher incidence of in-hospital complications than patients with coiled aneurysms, which attributes to a higher risk of poor functional outcome and death and an increased length of stay.




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